**THIS IS A CLOSEOUT ITEM THAT WILL ONLY BE AVAILABLE AS SUPPLIES LAST**
COLHIBIN PF is a paraben-free biological, rice-derived inhibitor of collagenase. Collagenases, also known as Matrix Metalloproteinases (MMP), are important factors for early skin aging. The impressive collagen protecting properties of COLHIBIN are proven by several exvivo studies on human MMP-1 and MMP-2 and its in-vivo efficacy is proven by a skin roughness study. Today skin is more and more stressed by the environmental conditions, COLHIBIN sets a new standard in reventing the skin from these stress factors. COLHIBIN is the result of a carefully isolated fraction of natural rice peptides. Rice has a very long and valuable tradition in human nutrition and COLHIBIN brings the vital properties of rice grains to our skin.
Skin is exposed to a great deal of stress, particularly ultraviolet (UV) radiation from the sun can lead to severe alterations and damage of skin cells and the extracellular matrix. This photodamage results in wrinkling, loss of thickness, increased fragility and premature aging. The changes in the skin are normally slow but persistent and begin to take place already at suberythemal doses of UV-irradiation. The destruction is therefore hardly remarked in the beginning. The UV-provoked induction of collagen degradation is derived from collagenases that are released in excess by skin cells like keratinocytes or fibroblasts. This is part of a natural defense reaction of the cells. In general, inflammatory skin disorders can increase the action of collagenase in the skin but it is also known that excessive collagenase is causing irritation and inflammation. These mechanisms have been demonstrated several times by skin research groups. Since slight irritations happen very frequently or they are permanently present, the activity of collagenase gets stepwise out of balance and leads to the breakdown of connective tissue. In particular the destruction of collagen results in the signs of skin aging, visible in the formation of wrinkles and decreasing elasticity. COLHIBIN is able to block the very damaging effect of collagenases induced by sun radiation, namely the collagen breakdown. For this reason, COLHIBIN represents a milestone in maintaining and restoring the collagen homeostasis of the skin and is ideally used as an anti-aging ingredient that is also able to elevate the moisture content of the skin.
COLHIBIN is a plant (rice) derived ingredient which protects the skin from the collagen degrading effects of collagenases induced either by UV-radiation or other skin irritants. Thereby, COLHIBIN helps to delay early skin aging, characterized by degeneration of matrix proteins, wrinkle formation, reduced elasticity and skin dryness. More advantages of COLHIBIN are taken from its moisturizing effect. For this reason, COLHIBIN is the ideal component for anti-aging products and is an excellent ingredient for the creation of new concepts for sun- and environmental stress protection formulations.
INCI: Hydrolyzed Rice Protein
This product should be added to a formulation at the recommended usage rate.
Shipping Info: HS# 3304300000
Statements contained herein have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat and cure or prevent disease. Always consult with your professional skin care provider.
California Prop 65 Statement: The following statement is made in order to comply with the California Safe Drinking Water and Toxic Enforcement Act of 1986. This product is not known to the State of California to cause cancer, birth defects or other reproductive harm.
Incorporation: COLHIBIN® PF can be processed either warm (< 70°C/158°F) or cold, and is incorporated into the water phase of a cosmetic formulation. COLHIBIN® PF is stable in the pH-range of 5.0 to 8. In formulations, COLHIBIN® PF is compatible with ethanol at concentrations of up to 20%.
Recommended Usage Rate: 2-5%
Appearance: Clear to slightly turbid, yellowish to amber solution
Manufacturer: DSM Nutritional Products Ltd.
Country of Origin: Switzerland
Solubility: Water soluble
pH: 5.3 - 6.3
Preservative: Phenoxyethanol and Sodium Benzoate
Storage: COLHIBIN PF should be stored in the original sealed containers protected from light in a clean and cool place at a preferred temperature between 2° and 8°C (35° - 46°F). In order to avoid secondary microbial contamination after opening, containers should be handled with special care. If stored under the recommended conditions, COLHIBIN PF remains stable for at least three years.