Tetrapeptide-21 Solution

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CAS#: 56-81-5, 107-88-0

Tetrapeptide-21 Solution is a novel bioactive and pure tetrapeptide with anti-aging properties based on the skin's own structures for use in skin care formulations. It activates collagen production and therefore stimulates dermal filling, repair and renewal mechanisms of the skin. 
Formulations with Tetrapeptide-21 Solution lead to an increased elasticity and a decreased volume of wrinkles and fine lines.  Those formulations containing 100 ppm (about 5% usage rate) Tetratrapeptide-21 Solution showed a 25% improvement in skin roughness and depth of fine and coarse wrinkles.

It is an ideal active ingredient to prevent and minimize the appearance of skin aging based on its collagen boosting activity, outperforming the current market standard (Matrixyl).

Tetrapeptide-21 Solution is a preservative-free peptide solution.  The cosmetic raw material should be kept under refrigeration until used in a properly preserved cosmetic formulation.

Tetrapeptide-21 Solution is suitable for oil-in-water and water-in-oil formulations claiming anti-aging and anti-wrinkle properties.

INCI: Tetrapeptide-21 (and) Glycerin (and) Butylene Glycol (and) Water

Do not directly apply onto your skin. This product should be added to a formulation at the recommended usage rate.

Statements contained herein have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat and cure or prevent disease. Always consult with your professional skin care provider.

California Prop 65 Statement: The following statement is made in order to comply with the California Safe Drinking Water and Toxic Enforcement Act of 1986. This product is not known to the State of California to cause cancer, birth defects or other reproductive harm.


  • For hot process formulations: Add at the end of the emulsion, at cool down, below 40C (104F). 
  • For cold process emulsions and gels, Tetrapeptide-21 Solution is added to the water phase and the emulsion is prepared as usual.

Recommended Usage Rate: 0.5-5%
Appearance: Colorless clear viscous liquid
Free Glycerin: 45 - 55%
Peptide Content: 2300 ppm

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